Medication Interaction Checker
Check what is documented to happen when a medication is combined with alcohol, over-the-counter sleep aids, other prescriptions, or common drug classes. Every entry below comes from FDA-approved prescribing information or an FDA Drug Safety Communication.
Important
This site provides educational information only and does not sell, prescribe or dispense medications. Always consult a licensed healthcare provider. This page is not medical advice.
Check a medication
Pick a drug to see its documented interactions, or jump to a drug class.
| Medication | Highest severity | Interactions |
|---|---|---|
| Adderall | Contraindicated | 7 |
| Xanax | Major | 9 |
| Fioricet | Major | 9 |
| Soma | Major | 7 |
| Klonopin | Major | 7 |
| Codeine | Contraindicated | 9 |
| Demerol | Contraindicated | 8 |
| Valium | Major | 7 |
| Fioricet, Butalbital/Acetaminophen/Caffeine | Contraindicated | 10 |
| Neurontin | Major | 3 |
| Vicodin, Vicodin ES, Vicodin HP, Norco, Lortab, Lorcet, Lorcet Plus | Contraindicated | 10 |
| Dilaudid | Contraindicated | 8 |
| Lexapro | Contraindicated | 3 |
| Ativan | Major | 6 |
| Lorcet, Lorcet Plus | Contraindicated | 6 |
| Lortab, Lortab ASA | Contraindicated | 6 |
| Methadone | Contraindicated | 9 |
| Modafinil | Contraindicated | 6 |
| Norco | Contraindicated | 6 |
| Roxicodone; Percocet | Contraindicated | 9 |
| OxyContin, Oxycodone Extended-Release | Contraindicated | 8 |
| Percocet | Contraindicated | 8 |
| Phentermine | Contraindicated | 6 |
| Roxicodone | Contraindicated | 8 |
| Suboxone, Suboxone Film | Contraindicated | 13 |
| Nucynta, Nucynta ER | Contraindicated | 8 |
| Ultram, Tramadol | Contraindicated | 9 |
| Viagra | Contraindicated | 6 |
| Vicodin, Vicodin ES, Vicodin HP | Contraindicated | 6 |
| Ambien | Major | 9 |
No medication matches that filter.
How to read the results
- Contraindicated means the labeling says do not combine. Stopping or starting either drug without prescriber direction can be dangerous.
- Major means the combination is usually avoided, or used only with explicit oversight and monitoring.
- Moderate means it is not an emergency, but it is worth raising with a pharmacist or prescriber.
Common interaction classes we cover
| Also checked against | Class |
|---|---|
| Alcohol (ethanol) | CNS depressant |
| Nitrates (nitroglycerin, isosorbide) | Nitrate vasodilator |
| MAO inhibitors (phenelzine, tranylcypromine, linezolid, methylene blue) | Monoamine oxidase inhibitor |
| Other serotonergic drugs (tramadol, SSRIs, SNRIs, triptans, St John's Wort, linezolid) | Serotonergic agent |
| Other benzodiazepines (diazepam, clonazepam, lorazepam, alprazolam, temazepam) | Benzodiazepine |
| Other opioids (morphine, fentanyl, methadone, oxycodone, hydromorphone, tramadol) | Opioid |
| Other gabapentinoids (gabapentin, pregabalin) | Gabapentinoid |
| Other Z-drugs (zolpidem, eszopiclone, zaleplon) | Sedative-hypnotic |
| Other sedatives (butalbital, barbiturates, carisoprodol, sedating antihistamines) | Sedative / barbiturate |
| Other CNS depressants (opioids, benzodiazepines, sleep aids, sedating antihistamines, gabapentinoids, muscle relaxants) | CNS depressant |
| Other stimulants (amphetamine, methamphetamine, methylphenidate, phentermine) | CNS stimulant |
| Warfarin and other vitamin K antagonists | Anticoagulant |
| Strong CYP3A4 inhibitors (ketoconazole, itraconazole, clarithromycin, ritonavir, grapefruit juice) | CYP3A4 inhibitor |
| Strong CYP3A4 inducers (rifampin, carbamazepine, phenytoin, St John's Wort) | CYP3A4 inducer |
| Cobicistat or ritonavir (HIV protease inhibitors) | Potent CYP3A inhibitor |
| Other acetaminophen-containing products (Tylenol, Excedrin, cold medicines) | Acetaminophen-containing product |
| Orexin receptor antagonists (suvorexant, lemborexant, daridorexant) | Sedative-hypnotic (dual orexin antagonist) |
| Other CNS-active antidepressants (mirtazapine, bupropion, TCAs) | CNS-active antidepressant |
| Serotonergic antiemetics (ondansetron, metoclopramide, granisetron, palonosetron) | Serotonergic agent |
| Opioid antagonists (naloxone, naltrexone, nalmefene) | Opioid antagonist |
| Antipsychotics (haloperidol, risperidone, olanzapine, quetiapine) | Antipsychotic |
| Antiparasitics (ivermectin, albendazole, praziquantel) | Antiparasitic |
| Flumazenil (benzodiazepine antagonist) | Benzodiazepine antagonist |
| Dopamine antagonists (phenothiazines, metoclopramide, haloperidol) | Dopamine antagonist |
| Other QT-prolonging drugs (class IA/III antiarrhythmics, some macrolides, haloperidol, methadone, ondansetron) | QT-prolonging agent |
| Sedating H1 antihistamines (diphenhydramine, hydroxyzine, chlorpheniramine, doxylamine, promethazine) | Sedating antihistamine |
| Beta blockers (metoprolol, propranolol, carvedilol, labetalol, atenolol, nadolol) | Beta blocker |
| Other MAO-type inhibitors (rasagiline, selegiline, safinamide) | Selective MAO-B inhibitor |
| Thyroid hormone replacement (levothyroxine) | Thyroid hormone |
| Insulin and sulfonylureas | Antidiabetic |
| Tricyclic antidepressants (amitriptyline, nortriptyline, imipramine, clomipramine) | Tricyclic antidepressant |
| Strong CYP3A inhibitors (ketoconazole, itraconazole, ritonavir, clarithromycin) | Strong CYP3A inhibitor |
| Fluoroquinolones (ciprofloxacin, levofloxacin, moxifloxacin) | Fluoroquinolone |
| Alpha-blockers (tamsulosin, doxazosin, terazosin) | Alpha-adrenergic blocker |
| Riociguat (soluble guanylate cyclase stimulator) | Soluble guanylate cyclase stimulator |
What this tool does not do
This checker covers a curated set of documented interactions between the medications on this site and the most common interacting drug classes. It is not a complete drug-interaction database and it cannot account for your full medication list, doses, kidney or liver function, or other conditions.
If a combination is not listed here, that is not a statement that it is safe. Your pharmacist has access to interaction screening software that covers the full drug database, and they should be the final check before you start or stop any medication.