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Adderall Interactions: What to Avoid

Documented interactions for Adderall (amphetamine (mixed salts of a single entity: dextroamphetamine sulfate, amphetamine sulfate, dextroamphetamine saccharate, amphetamine aspartate; 3:1 d:l ratio)). Each entry cites the prescribing information or FDA safety communication it is based on.

2 contraindicated5 moderate

Interaction summary

SeverityInteracts withClassConcern
ContraindicatedMAO inhibitors (phenelzine, tranylcypromine, linezolid, methylene blue)Monoamine oxidase inhibitorMixed amphetamine salts with MAO inhibitors is contraindicated
ContraindicatedMAO inhibitors (phenelzine, tranylcypromine, linezolid, methylene blue)Monoamine oxidase inhibitorStimulant with MAO inhibitors is contraindicated
ModerateOther benzodiazepines (diazepam, clonazepam, lorazepam, alprazolam, temazepam)BenzodiazepineBenzodiazepines may counteract stimulant adverse effects
ModerateOther serotonergic drugs (tramadol, SSRIs, SNRIs, triptans, St John's Wort, linezolid)Serotonergic agentMixed amphetamine salts with serotonergic drugs
ModerateOther serotonergic drugs (tramadol, SSRIs, SNRIs, triptans, St John's Wort, linezolid)Serotonergic agentStimulant with serotonergic drugs
ModerateOther stimulants (amphetamine, methamphetamine, methylphenidate, phentermine)CNS stimulantAdditive cardiovascular and psychiatric effects with other stimulants
ModerateSerotonergic antiemetics (ondansetron, metoclopramide, granisetron, palonosetron)Serotonergic agentAdditive serotonergic effects with serotonergic antiemetics

Detailed interactions

Contraindicated

Mixed amphetamine salts with MAO inhibitors is contraindicated

With: MAO inhibitors (phenelzine, tranylcypromine, linezolid, methylene blue) Monoamine oxidase inhibitor

Why it happens

Amphetamines release catecholamines; MAO inhibitors prevent their breakdown, causing extreme sympathetic activity.

What can happen

Severe hyperadrenergic crisis: extreme hypertension, hyperthermia, agitation, seizures, and death.

What to do

The combination is contraindicated. Allow at least 14 days between an MAOI and a sympathomimetic.

Basis: Mixed amphetamine salts extended-release tablets prescribing information, Contraindications. source

Contraindicated

Stimulant with MAO inhibitors is contraindicated

With: MAO inhibitors (phenelzine, tranylcypromine, linezolid, methylene blue) Monoamine oxidase inhibitor

Why it happens

Sympathomimetic amines release catecholamines; MAO inhibitors prevent their breakdown.

What can happen

Extreme hyperadrenergic crisis with hypertension, hyperthermia, and seizures.

What to do

Do not combine; a washout period is required.

Basis: Stimulant prescribing information, Contraindications. source

Moderate

Benzodiazepines may counteract stimulant adverse effects

With: Other benzodiazepines (diazepam, clonazepam, lorazepam, alprazolam, temazepam) Benzodiazepine

Why it happens

Benzodiazepines are used clinically to treat stimulant-induced agitation and tremor.

What can happen

Coadministration may reduce the jitteriness and insomnia of stimulants, which can mask toxicity and increase misuse potential.

What to do

This is not necessarily dangerous but should be a deliberate clinical decision, not self-medication.

Basis: Mixed amphetamine salts prescribing information, Drug Interactions. source

Moderate

Mixed amphetamine salts with serotonergic drugs

With: Other serotonergic drugs (tramadol, SSRIs, SNRIs, triptans, St John's Wort, linezolid) Serotonergic agent

Why it happens

Amphetamine has serotonergic activity in addition to catecholamine release.

What can happen

Labeling notes the risk of serotonin syndrome with other serotonergic agents in some contexts.

What to do

Tell your prescriber about antidepressants and other serotonergic medications.

Basis: Mixed amphetamine salts prescribing information, Warnings. source

Moderate

Stimulant with serotonergic drugs

With: Other serotonergic drugs (tramadol, SSRIs, SNRIs, triptans, St John's Wort, linezolid) Serotonergic agent

Why it happens

Additive serotonergic activity.

What can happen

Serotonin syndrome is possible.

What to do

Disclose antidepressants to the prescriber.

Basis: Stimulant prescribing information, Warnings. source

Moderate

Additive cardiovascular and psychiatric effects with other stimulants

With: Other stimulants (amphetamine, methamphetamine, methylphenidate, phentermine) CNS stimulant

Why it happens

Two sympathomimetics increase catecholamine activity.

What can happen

Increased risk of tachycardia, hypertension, insomnia, agitation, and psychotic symptoms.

What to do

Prescribers should review the full stimulant list and monitor blood pressure and heart rate.

Basis: Mixed amphetamine salts prescribing information, Warnings and Precautions. source

Moderate

Additive serotonergic effects with serotonergic antiemetics

With: Serotonergic antiemetics (ondansetron, metoclopramide, granisetron, palonosetron) Serotonergic agent

Why it happens

Increased serotonergic tone from two drug classes.

What can happen

Serotonin syndrome is possible.

What to do

Mention antiemetics, including ondansetron, to your prescriber.

Basis: Mixed amphetamine salts prescribing information, Warnings. source

Common questions

What should I know about Adderall interactions?

We have documented 7 interaction classes for Adderall in our dataset. Usually avoided, or used only with explicit prescriber oversight and close monitoring. The most serious items on this page are marked contraindicated or major.

Can I take Adderall with alcohol?

Alcohol interacts with most of the medications on this site because it adds to sedation and slows breathing. For the specific documented risk, see the relevant entry above. The general rule from labeling is to avoid alcohol.

Does an empty result mean Adderall is safe with other drugs?

No. An empty result only means our curated dataset has no matching rule. A pharmacist can run a full interaction screen against every medication and supplement you take.

Related

Editorial Review Board

Clinical review by licensed pharmacists (PharmD)

Every page on this site is reviewed against current FDA prescribing information, DailyMed labelling, DEA scheduling regulations and MedlinePlus monographs before publication. Reviewers have no commercial relationship with any manufacturer or pharmacy.

Last substantive review: October 01, 2026

Sources & references

MedlinePlus drug information (National Library of Medicine)
PubChem compound record (National Institutes of Health)
21 CFR Part 1308 — Controlled Substances (eCFR)
Drug Enforcement Administration — drug scheduling

Important

This site provides educational information only and does not sell, prescribe or dispense medications. Always consult a licensed healthcare provider. This page is not medical advice.