Documented interactions for Soma (carisoprodol). Each entry cites the prescribing information or FDA safety communication it is based on.
| Severity | Interacts with | Class | Concern |
|---|---|---|---|
| Major | Alcohol (ethanol) | CNS depressant | Carisoprodol with alcohol: additive CNS depression |
| Major | Alcohol (ethanol) | CNS depressant | Sedative with alcohol: additive CNS depression |
| Major | Other CNS depressants (opioids, benzodiazepines, sleep aids, sedating antihistamines, gabapentinoids, muscle relaxants) | CNS depressant | Sedative with other CNS depressants |
| Major | Other opioids (morphine, fentanyl, methadone, oxycodone, hydromorphone, tramadol) | Opioid | Carisoprodol with opioids: additive CNS and respiratory depression |
| Major | Other opioids (morphine, fentanyl, methadone, oxycodone, hydromorphone, tramadol) | Opioid | Sedative with opioids: additive respiratory depression |
| Moderate | Orexin receptor antagonists (suvorexant, lemborexant, daridorexant) | Sedative-hypnotic (dual orexin antagonist) | Sedative with orexin receptor antagonists: additive CNS depression |
| Moderate | Other CNS depressants (opioids, benzodiazepines, sleep aids, sedating antihistamines, gabapentinoids, muscle relaxants) | CNS depressant | Carisoprodol with other CNS depressants: additive sedation |
With: Alcohol (ethanol) CNS depressant
Combined central nervous system depression.
Impaired judgment and coordination, sedation, and respiratory depression.
Avoid alcohol during carisoprodol therapy.
Basis: Carisoprodol tablets prescribing information, Warnings and Precautions. source
With: Alcohol (ethanol) CNS depressant
Combined central nervous system depression.
Respiratory depression, deep sedation, and death.
Avoid alcohol.
Basis: Sedative-hypnotic prescribing information, Warnings. source
With: Other CNS depressants (opioids, benzodiazepines, sleep aids, sedating antihistamines, gabapentinoids, muscle relaxants) CNS depressant
Additive central nervous system depression.
Excessive sedation and respiratory depression.
Review all sedating medications with the prescriber.
Basis: Sedative-hypnotic prescribing information, Drug Interactions. source
With: Other opioids (morphine, fentanyl, methadone, oxycodone, hydromorphone, tramadol) Opioid
Centrally acting muscle relaxants depress the central nervous system and compound opioid sedation.
Excessive sedation and respiratory depression.
Use caution and monitor for sedation and slowed breathing.
Basis: Carisoprodol tablets prescribing information, Drug Interactions. source
With: Other opioids (morphine, fentanyl, methadone, oxycodone, hydromorphone, tramadol) Opioid
Additive central nervous system and respiratory depression.
Respiratory depression and overdose.
Avoid where possible; monitor for slowed breathing.
Basis: Sedative-hypnotic prescribing information, Drug Interactions. source
With: Orexin receptor antagonists (suvorexant, lemborexant, daridorexant) Sedative-hypnotic (dual orexin antagonist)
Additive sedative effects from two sleep-promoting drug classes.
Excessive sedation and impaired coordination.
Only one sleep medication should generally be used at a time.
Basis: Sleep medication prescribing information, Drug Interactions. source
With: Other CNS depressants (opioids, benzodiazepines, sleep aids, sedating antihistamines, gabapentinoids, muscle relaxants) CNS depressant
Additive central nervous system depression.
Sedation and impaired coordination.
Discuss all sedating medications with the prescriber.
Basis: Carisoprodol tablets prescribing information, Drug Interactions. source
We have documented 7 interaction classes for Soma in our dataset. Usually avoided, or used only with explicit prescriber oversight and close monitoring. The most serious items on this page are marked contraindicated or major.
Alcohol interacts with most of the medications on this site because it adds to sedation and slows breathing. For the specific documented risk, see the relevant entry above. The general rule from labeling is to avoid alcohol.
No. An empty result only means our curated dataset has no matching rule. A pharmacist can run a full interaction screen against every medication and supplement you take.
This site provides educational information only and does not sell, prescribe or dispense medications. Always consult a licensed healthcare provider. This page is not medical advice.