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Percocet (Oxycodone + acetaminophen): uses, side effects and safety

Quick answer

Oxycodone (Percocet) is a opioid analgesic combination product. It is a US Schedule II controlled substance. It is prescription only (rx) and remains on the US market.

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Last substantive review: October 01, 2026

What is Oxycodone?

Oxycodone is the generic name for Percocet, and belongs to the Opioid analgesic combination product class.

Generic nameOxycodone HCl and acetaminophen (tablet)
Brand name(s)Percocet
Drug classOpioid analgesic combination product
US legal statusUS Schedule II ยท Prescription only (Rx)
RouteOral
Prescription requiredYes

How does Oxycodone work?

Oxycodone is an opioid agonist; acetaminophen is a non-opioid analgesic and antipyretic..

Common side effects of Oxycodone

These are the side effects people report most often. Many diminish after the body adjusts, usually within one to two weeks.

  • lightheadedness
  • dizziness
  • drowsiness or sedation
  • nausea
  • vomiting
  • euphoria
  • dysphoria
  • constipation
  • pruritus

Serious side effects and warning signs

Seek emergency care for any of these

  • respiratory depression, apnea, respiratory arrest
  • circulatory depression, hypotension, shock
  • addiction/abuse/misuse
  • neonatal opioid withdrawal syndrome
  • severe liver injury from acetaminophen
  • hypersensitivity reactions

Suspected overdose or a bad reaction should be reported to Poison Control on 1-800-222-1222. That is staffed around the clock and is free.

Oxycodone is a Schedule II controlled substance in the United States. That placement is set out in Title 21 of the Code of Federal Regulations, Part 1308, and enforced by the Drug Enforcement Administration. It carries restrictions on prescribing, storage, record-keeping and transfer.

Statutory reference: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=4dd36cf5-8f73-404a-8b1d-3bd53bd90c25.

Can you get Oxycodone without a prescription?

Short answer: no. Oxycodone is a prescription medication. Sites advertising it without one are either operating illegally or selling something other than what they claim. We explain the legal routes, the counterfeit problem and how to check a source in detail.

Read the full answer: Oxycodone without a prescription →

Related medications

Codeine

Opioid analgesic

Medication information page.

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Propoxyphene

Narcotic (opioid) analgesic combination product

Medication information page.

Read more →

Meperidine

Opioid analgesic

Medication information page.

Read more →

Frequently asked questions

What is Oxycodone used for?

See the approved uses section below.

What schedule is Oxycodone in the United States?

Oxycodone is a Schedule II controlled substance in the US, listed at 21 CFR Part 1308. Schedule II means the drug has a defined potential for abuse and is subject to federal record-keeping, storage and prescribing restrictions.

What are the common side effects of Oxycodone?

The most frequently reported side effects are lightheadedness, dizziness, drowsiness or sedation, nausea, vomiting, euphoria. Many lessen over the first week or two of treatment.

Important

This site provides educational information only and does not sell, prescribe or dispense medications. Always consult a licensed healthcare provider. This page is not medical advice.