Meperidine: uses, side effects and safety
Meperidine (Demerol) is a opioid analgesic. It is a US Schedule II controlled substance. It is prescription only (rx) and remains on the US market.
What is Meperidine?
Meperidine is the generic name for Demerol, and belongs to the Opioid analgesic class.
| Generic name | Meperidine (tablet and injection) |
|---|---|
| Brand name(s) | Demerol |
| Drug class | Opioid analgesic |
| US legal status | US Schedule II ยท Prescription only (Rx) |
| Route | Oral |
| Prescription required | Yes |
| Elimination half-life | 2-5 |
How does Meperidine work?
Opioid agonist analgesic..
The elimination half-life is roughly 2-5. Longer half-lives mean the drug and its active metabolites persist in the body for longer after the last dose.
Common side effects of Meperidine
These are the side effects people report most often. Many diminish after the body adjusts, usually within one to two weeks.
- lightheadedness
- dizziness
- sedation
- nausea
- vomiting
- sweating
- constipation
Serious side effects and warning signs
Seek emergency care for any of these
- respiratory depression
- addiction/abuse/misuse
- normeperidine-related toxicity (label Limitations of Use)
- neonatal opioid withdrawal syndrome
- overdose
- precipitated withdrawal when combined with mixed agonist/antagonist or partial agonist analgesics
Suspected overdose or a bad reaction should be reported to Poison Control on 1-800-222-1222. That is staffed around the clock and is free.
Legal status of Meperidine
Meperidine is a Schedule II controlled substance in the United States. That placement is set out in Title 21 of the Code of Federal Regulations, Part 1308, and enforced by the Drug Enforcement Administration. It carries restrictions on prescribing, storage, record-keeping and transfer.
Statutory reference: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b31d1308-28c3-43f4-e0a6-2f3ed76b8975.
Can you get Meperidine without a prescription?
Short answer: no. Meperidine is a prescription medication. Sites advertising it without one are either operating illegally or selling something other than what they claim. We explain the legal routes, the counterfeit problem and how to check a source in detail.
Read the full answer: Meperidine without a prescription →
Related medications
Propoxyphene
Narcotic (opioid) analgesic combination productMedication information page.
Read more →Butalbital
Non-opioid analgesic combination product (barbiturate, analgesic and stimulant)Medication information page.
Read more →Frequently asked questions
What is Meperidine used for?
See the approved uses section below.
What schedule is Meperidine in the United States?
Meperidine is a Schedule II controlled substance in the US, listed at 21 CFR Part 1308. Schedule II means the drug has a defined potential for abuse and is subject to federal record-keeping, storage and prescribing restrictions.
What are the common side effects of Meperidine?
The most frequently reported side effects are lightheadedness, dizziness, sedation, nausea, vomiting, sweating. Many lessen over the first week or two of treatment.
Sources & references
Important
This site provides educational information only and does not sell, prescribe or dispense medications. Always consult a licensed healthcare provider. This page is not medical advice.