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OxyMORPHONE: uses, side effects and safety

Quick answer

OxyMORPHONE (Opana ER) is a opioid analgesic. It is a US Schedule II controlled substance. It is prescription only (rx) and is no longer marketed in the US. .

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Last substantive review: October 01, 2026

What is OxyMORPHONE?

OxyMORPHONE is the generic name for Opana ER, and belongs to the Opioid analgesic class.

Generic nameOxyMORPHONE HCl (extended-release tablet)
Brand name(s)Opana ER
Drug classOpioid analgesic
US legal statusUS Schedule II · Prescription only (Rx) · Product discontinued
RouteOral
Prescription requiredYes
Elimination half-life9.35-11.30
Time to peak concentration1.5

How does OxyMORPHONE work?

Opioid agonist..

The elimination half-life is roughly 9.35-11.30. Longer half-lives mean the drug and its active metabolites persist in the body for longer after the last dose.

Common side effects of OxyMORPHONE

These are the side effects people report most often. Many diminish after the body adjusts, usually within one to two weeks.

  • nausea
  • constipation
  • dizziness (excluding vertigo)
  • vomiting
  • pruritus
  • somnolence
  • headache
  • increased sweating
  • sedation

Serious side effects and warning signs

Seek emergency care for any of these

  • respiratory depression
  • addiction/abuse/misuse
  • neonatal opioid withdrawal syndrome
  • overdose

Suspected overdose or a bad reaction should be reported to Poison Control on 1-800-222-1222. That is staffed around the clock and is free.

OxyMORPHONE is a Schedule II controlled substance in the United States. That placement is set out in Title 21 of the Code of Federal Regulations, Part 1308, and enforced by the Drug Enforcement Administration. It carries restrictions on prescribing, storage, record-keeping and transfer.

Statutory reference: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=5ca97412-1594-4a4e-b5e4-8593ffa1b242.

Can you get OxyMORPHONE without a prescription?

Short answer: no. OxyMORPHONE is a prescription medication. Sites advertising it without one are either operating illegally or selling something other than what they claim. We explain the legal routes, the counterfeit problem and how to check a source in detail.

Read the full answer: OxyMORPHONE without a prescription →

Related medications

Codeine

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Propoxyphene

Narcotic (opioid) analgesic combination product

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Meperidine

Opioid analgesic

Medication information page.

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Frequently asked questions

What is OxyMORPHONE used for?

See the approved uses section below.

What schedule is OxyMORPHONE in the United States?

OxyMORPHONE is a Schedule II controlled substance in the US, listed at 21 CFR Part 1308. Schedule II means the drug has a defined potential for abuse and is subject to federal record-keeping, storage and prescribing restrictions.

What are the common side effects of OxyMORPHONE?

The most frequently reported side effects are nausea, constipation, dizziness (excluding vertigo), vomiting, pruritus, somnolence. Many lessen over the first week or two of treatment.

Important

This site provides educational information only and does not sell, prescribe or dispense medications. Always consult a licensed healthcare provider. This page is not medical advice.